Lyomax Series Freeze-Drying
Machine overview
Beyond Limits.
Although freeze-drying is one of the oldest techniques in the pharmaceutical industry for the preservation of unstable materials, there has been an increasing demand for lyophilized products and equipment, in particular in the last decade. In fact, today, about half of all sterile injectables are lyophilized.
Today’s freeze-drying process demands increased process control, with reduced processing time augmented with upgrades in equipment to remain compliant with a changing regulatory landscape. To accommodate such growth, IMA Life uses its in-depth process knowledge to make freeze-drying faster, safer, cheaper, and compatible with all industry requirements and challenges.
Lyomax configurable options and custom designs provide the optimal solution for each application.
Lyomax meets the highest possible technical requirements, the strictest standards of the global licensing authorities, and complies with all the current guidelines such as GAMP, cGMP, FDA etc.
Production plant
IMA Life
Machine highlights
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Machine dimensions
Machine sizes from 1 m2 to 100 m2.
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Multiple configurations
Configurations including integral condenser, external condenser, two-storey and pass-through designs.
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Refrigeration system
Two-stage reciprocating semi-hermetic/screw compressors/liquid nitrogen refrigeration system.
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Cooling
Shelf cooling to -55/70°C and condenser cooling to -75/120°C. HFC/LN2 refrigerants.
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Integrated loading/unloading systems
Integrated automatic, semi-automatic and manual loading/unloading systems.
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Vacuum measurements
Vacuum measurements with capacitance manometers.
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KRYOSEQ® technology
KRYOSEQ® advanced technology using sterile liquid nitrogen to control the nucleation process during pharmaceutical freeze-drying.
Multiple configurations
The Lyomax Series offers the most comprehensive range of custom-built freeze dryers for those who require more than a standard solution. LYOMAX can provide the answer from 1 m2 to 100 m2 applying state-of-the-art engineering in vacuum, refrigeration, stoppering and heat-transfer technology.
IMA Life’s FUSION™ – FUSION PLUS™ shelves
Lyomax shelves are designed and manufactured with IMA Life’s patented FUSION™ technology, to ensure higher quality and enhance process reliability. The FUSION™ – FUSION PLUS™ shelves are lighter and more resistant than conventional solutions and offer enhanced heat transfer properties.
Machine details
Technical information
| Model | Number of shelves | Vial pack area Manual loading (m2) | Vial pack (wxd) Manual loading (mm) | Vial pack area Auto loading (m2) | Vial pack (wxd) Auto loading (mm) | Condenser capacity (kg @12.7 mm ice) | Compressor configuration | LN2 configuration | KryoAir configuration |
| LYOMAX 1 | 5 | 1.4 | 455 x 615 | NA | NA | 28 | 2 x 5Hp Bitzer | LF25/12 | 1 x 23T-0 |
| LYOMAX 3 | 5 | 2.8 | 615 x 916 | 2.6 | 615 x 837 | 70 | 2 x 8Hp Bitzer | LF25/12 | 1 x 23T-0 |
| LYOMAX 5 | 6 | 5 | 916 x 916 | 4.6 | 916 x 837 | 97 | 2 x 12Hp Bitzer | LF25/12 | 1 x 23T-1 |
| LYOMAX 7 | 7 | 7.8 | 916 x 1,220 | 7,.3 | 916 x 1,141 | 143 | 2 x 16 Hp Bitzer | LF50/20 | 1 x 23T-1 |
| LYOMAX 10 | 9 | 10 | 916 x 1,220 | 9.4 | 916 x 1,141 | 194 | 2 x 20Hp Bitzer | LF50/20 | 1 x 23T-1 |
| LYOMAX 15 | 10 | 14.5 | 1,220 x 1,220 | 13.9 | 1,220 x 1,141 | 273 | 2 x 30Hp Mycom | LF50/20 | 2 x 23T-1 |
| LYOMAX 20 | 11 | 20.5 | 1,220 x 1,524 | 19.4 | 1,220 x 1445 | 375 | 2 x 30Hp Mycom | LF50/20 | 1 x 80T-0 |
| LYOMAX 25 | 14 | 26 | 1,220 x 1,524 | 24.6 | 1,220 x 1,445 | 476 | 2 x 50Hp Mycom | LF100/50 | 1 x 80T-1 |
| LYOMAX 30 | 13 | 30.2 | 1,524 x 1,524 | 28.6 | 1,524 x 1,445 | 552 | 2 x 50Hp Mycom | LF100/50 | 1 x 80T-1 |
| LYOMAX 35 | 13 | 36.3 | 1,524 x 1,830 | 34.7 | 1,524 x 1,751 | 635 | 2 x 50Hp Mycom | LF100/50 | 1 x 80T-1 |
| LYOMAX 40 | 15 | 41.8 | 1,524 x 1,830 | 40 | 1,524 x 1,751 | 731 | 2 x 50Hp Mycom | LF100/50 | 2 x 80T-0 |
| Minimum shelf temperature (5cst/1/6cst oil) | -55C/-60C | -65C | -60C | ||||||
| Minimum condenser temperature | -75C | -100C | -75C | ||||||
